06Jun

Patient monitoring technology has proven both a boon and, in some ways, a burden to medical science.

Automatic sensors can detect heart fluctuations, sounding an alarm that will bring staff running. Other sensors monitor respiration, brain activity, temperature and multiple other critical factors, alerting professionals when help is needed.

However, these monitors can be so sensitive they send alerts for even minor departures from preset norms. A busy surgical unit can be a noisy place with alarms going off so frequently for little reason that they become part of the background ambiance, causing what medical professionals call “alarm fatigue.”

In one large study, nurses in a busy urban hospital were bombarded by an average of 187 alarms per bed each day. Of the 2,558,760 alarms recorded during the month-long study, most – up to 95% — were false or of little consequence.

So serious is alarm fatigue that in 2013 The Joint Commission issued a Sentinel Event Alert warned about the potential for desensitization. “In response to this constant barrage of noise, clinicians may turn down the volume of the alarm, turn it off, or adjust the alarm settings outside the limits that are safe and appropriate for the patient – all of which can have serious, often fatal, consequences.”

Still listed as one of the “Top 10 Health Technology Hazards” by the Emergency Care Research Institute, there is hope that yet another technological advance may hold the solution to too many alarms.

At Johns Hopkins, the health system’s alarms committee has been using and testing a number of techniques for quieting unnecessary alarms. Among these is the use of algorithms to decide when to sound an alarm, to whom and when and how to escalate the situation.

A more extensive use of artificial intelligence was discussed last fall in the Journal of Medical Internet Research. Researchers tested their AI algorithms against the recorded data from 32 surgical patients in Australia. Their technology reduced the total number of alarms by 99.3%.

Although it was not used in an actual clinical environment, “The experimental results strongly suggest that this reasoning algorithm is a useful strategy for avoiding alarm fatigue,” they wrote.

Using artificial intelligence to decide when and how to sound an alarm is still in the future. But, notes The Medical Futurist, “With time, AI solutions will be incorporated in patient monitors as a built-in “smart alarm system” throughout hospital units.”

Image by Bokskapet

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Jun 6, 2023

Study Finds Cats Can Benefit Kids with Autism

Dogs are the most common service animal, but for children with autism spectrum disorder, cats may be more therapeutic.

A new study reported in the Journal of Pediatric Nursing found ordinary shelter cats had a calming effect on children with ASD, improving their empathy toward others while reducing bullying, hyperactivity and separation anxiety.

“Cats, and companion animals in general, offer unconditional acceptance and someone to talk to that listens, and caring for an animal can help with learning responsibility,” said study author Gretchen Carlisle, a research scientist at the Research Center for Human-Animal Interaction at the University of Missouri veterinary college.

But dogs require more care and attention than cats, adding to the burden parents of children with autism already face.

They also are more active and energetic, which can trigger autistic children.

“Many children with autism have sensory issues and when a dog is barking in your face, it can be really overwhelming, whereas cats just sit beside you and are less overwhelming from a sensory standpoint,” Carlisle explained.

Her small study followed 11 families with autistic children ages 6-14. One group of families adopted a shelter cat and was followed for 18 weeks. A second group without a cat was followed for 18 weeks, then adopted a cat for another 18 weeks.

“Our study,” the researchers wrote, ”Found cat adoption was associated with greater empathy and less separation anxiety for children with ASD, along with fewer problem behaviors including externalizing, bullying and hyperactivity/inattention. Parents and children reported strong bonds to the cats.”

All the cats were screened for a calm temperament. “We specifically selected cats aged 10 months to 4 years because there is prior work that younger cats are more social with kids with autism, and adult temperament tends to be set at 10 months with cats, so these are younger cats with an adult temperament,” Carlisle told HealthDay News.

Commenting on the study, Dr. Melissa Nishawala, director of the Autism Spectrum Disorder Research and Clinical Program at Hassenfeld Children’s Hospital at NYU Langone Health in New York City, said that though the study was small, “these are promising findings that mirror what I see in practice.”

Photo by Andriyko Podilnyk

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Jun 6, 2023

Statins Show Promise in Reducing Death from Ovarian Cancer

Women with ovarian cancer who take statins to lower their cholesterol have a 40% lower death rate.

“These drugs are appealing as they are widely used, inexpensive, and well tolerated in most patients. The associated reduction in ovarian cancer mortality is promising,” said Dr. Kala Visvanathan, lead researcher of a new study presented last week during the American Association for Cancer Research Virtual Annual Meeting II.

Dr. Visvanathan, professor of epidemiology and oncology at Johns Hopkins Bloomberg School of Public Health and Sidney Kimmel Comprehensive Cancer Center in Baltimore, said all statins reduced the risk of dying, with lipophilic statins such as simvastatin and lovastatin, decreasing the likelihood by an average 43%. The most significant reductions occurred in those with high-grade serous carcinoma (40% reduction in mortality) and endometrioid ovarian cancer (50% reduction.)

The findings are the most comprehensive to date and add support to other, smaller studies showing similar improvements in ovarian cancer mortality from statins.

Most recently, a team of researchers at Australia’s QIMR Berghofer Medical Research Institute, analyzed 36 studies of several common medications taken by ovarian cancer patient. They concluded statin use showed the most promise. “Statin use is associated with better ovarian cancer survival,” they wrote in an article this month in Gynecologic Oncology, cautioning that, “Further study, preferably a clinical trial, is required.”

At the AACR meeting, Visvanathan said her team reviewed data on 10,062 ovarian cancer patients from the Finnish national cancer registry. 2,621 used statins, and 80% of those used lipophilic statins.

“Our results provide further evidence in support of the clinical evaluation of lipophilic statins as part of the treatment of ovarian cancer,” Visvanathan said.

Ovarian cancer is a rare cancer type, accounting for only about 1.2% of cancer cases diagnosed in the United States each year. Its five year survival rate is less than 50% because of the difficulty of diagnosing it until it has progressed to an advanced stage.

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