Associate Scientist II

Job Title: Associate Scientist II

Job Description

Overview

The successful candidate will be a part of the Process Chemistry group, responsible for the process development and in-house non-GMP manufacture of modified oligonucleotides and siRNAs.

Summary of Key Responsibilities

·        Support non-GMP oligonucleotide production on a tight timeline

·        Support purification method development, optimization, and scale-up

·        Execute non-GMP oligonucleotide purifications

·        Execute downstream processing of purified material

·        Execute in-process analytical tests

·        Participate in creating and reviewing SOPs and batch records

·        Support campaign activities across other unit operations as needed

 Qualifications

·        BS in Chemistry with 1-3 years lab experience, preferably in an industrial setting.

·        Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred. Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.

·        Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance.

·        Good communication skill is a must for this position. The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.