06Jun

Osteoarthritis of the knee is a common condition in humans and in their canine companions. An estimated 20% of dogs older than a year and 12% of people between 25 and 74 will develop the condition.

The causes and mechanisms are not well understood, however age and weight are considered major risk factors.

Injuries also lead to developing the disease. In fact one of the most common of all sports injuries in humans as well as dogs – a tear of the anterior cruciate ligament — is the leading cause of post traumatic osteoarthritis.

The mystery is why many, but not all, dogs and people with ACL injuries develop post traumatic osteoarthritis, medically referred to as PTOA. Now, a study of dogs at Cornell University’s veterinary school, published this month in Scientific Reports, offers clues to the potential for developing PTOA.

Researchers led by Dr. Heidi Reesink, assistant professor in equine health at Cornell, found that changes in the production of lubricin, a joint lubricating protein, could be a precursor to developing joint disease.

Lubricin is critical to smooth joint functioning. “We know that if a person or animal doesn’t make that protein, they will develop devastating joint disease affecting all the major weight-bearing joints,” says Reesink.

The prevailing view among veterinarians and physicians is that lubricin production declines after injury, leading to the development of PTOA. “The dogma in this field has been that lubricin decreases in joint disease,” Reesink said.

But the study found that in canine patients with a knee ligament tear lubricin increased and it was correlated with the development of osteoarthritis.

“This indicates that the presence of increased lubricin might actually be a biomarker for predicting future osteoarthritis,” said Reesink. “We also saw increased lubricin in dogs months to years after they injured their ACLs, suggesting that lubricin might be an indicator of ongoing joint instability.”

Increased lubricin could serve as a tipoff to clinicians to intervene with early treatments to ward off or slow the development of osteoarthritis, not just in dogs, but in people, too.

Photo by Alvan Nee on Unsplash

[bdp_post_carousel]

Jun 6, 2023

Nation Starts Recruiting 100,000 Contact Tracers to ‘Box-in’ COVID-19

An army of workers is being recruited across the US to help “box-in” the coronavirus to prevent its spread and reduce the chance of new outbreaks.

Tens of thousands – 100,000 at least — of these special workers will be deployed to track down and counsel individuals who may have come into contact with an infected person. When they do, they’ll ask them about their health, informing them they were potentially exposed to the virus and advising them about what steps to take.

These contact tracers may also ask them who they’ve been in contact with and then reach out to those individuals as well.

Contact tracing is a key part of how public health officials will contain the spread of COVID-19.

Described in a document prepared by the Association of State and Territorial Health Officials, boxing-in the virus involves four tactics: “(1) testing, (2) isolation of all infected people, (3) finding everyone who has been in contact with infected people, (4) quarantine all contacts for 14 days, and (1) re-testing of those people.”

Each piece is essential to containing the pandemic, but success depends first on identifying the infected and who they may have infected, which is why so many cities and states have begun beefing up the ranks of their public health investigators.

“Contact tracing, monitoring, and provision of social supports to infected individuals and their contacts is an urgent priority of local, state, territorial, and tribal health departments,” says the association, “And will require rapid and massive scaling up of existing contact investigation resources in every community in the United States and its territories.”

As recruiting for these positions gets underway, agencies are making a determined effort to recruit from the ethnic and minority communities most impacted by COVID-19, reports Kaiser Health News.

“There are some communities that aren’t going to respond to a phone call, a text message or a letter,” explains Dr. Kara Odom Walker, secretary of the Delaware Department of Health and Social Services. “That could be due to health literacy issues, which could be due to fear, or documentation status.”

In Long Beach, California, which has a substantial Cambodian, Vietnamese, Samoan, Pilipino and Spanish-speaking population, the city weeks ago assembled a team of 60 contact tracers and interpreters from among its bilingual municipal workers.

Virginia, which plans to hire 1,300 tracers and support staff, is recruiting speakers of Mandarin, Haitian Creole, Spanish and Bengali, according to the Kaiser report.

Having a tracer who understands the culture as well as speaks the language can make a big difference in how much cooperation – and success – public health agencies will have.

Says Walker, “You need someone to be a cultural broker to say, not only are these policies in place to protect you, but I’m telling you to trust me that this will be OK.”

Photo by Martin Sanchez on Unsplash

[bdp_post_carousel]