06Jun

Patient monitoring technology has proven both a boon and, in some ways, a burden to medical science.

Automatic sensors can detect heart fluctuations, sounding an alarm that will bring staff running. Other sensors monitor respiration, brain activity, temperature and multiple other critical factors, alerting professionals when help is needed.

However, these monitors can be so sensitive they send alerts for even minor departures from preset norms. A busy surgical unit can be a noisy place with alarms going off so frequently for little reason that they become part of the background ambiance, causing what medical professionals call “alarm fatigue.”

In one large study, nurses in a busy urban hospital were bombarded by an average of 187 alarms per bed each day. Of the 2,558,760 alarms recorded during the month-long study, most – up to 95% — were false or of little consequence.

So serious is alarm fatigue that in 2013 The Joint Commission issued a Sentinel Event Alert warned about the potential for desensitization. “In response to this constant barrage of noise, clinicians may turn down the volume of the alarm, turn it off, or adjust the alarm settings outside the limits that are safe and appropriate for the patient – all of which can have serious, often fatal, consequences.”

Still listed as one of the “Top 10 Health Technology Hazards” by the Emergency Care Research Institute, there is hope that yet another technological advance may hold the solution to too many alarms.

At Johns Hopkins, the health system’s alarms committee has been using and testing a number of techniques for quieting unnecessary alarms. Among these is the use of algorithms to decide when to sound an alarm, to whom and when and how to escalate the situation.

A more extensive use of artificial intelligence was discussed last fall in the Journal of Medical Internet Research. Researchers tested their AI algorithms against the recorded data from 32 surgical patients in Australia. Their technology reduced the total number of alarms by 99.3%.

Although it was not used in an actual clinical environment, “The experimental results strongly suggest that this reasoning algorithm is a useful strategy for avoiding alarm fatigue,” they wrote.

Using artificial intelligence to decide when and how to sound an alarm is still in the future. But, notes The Medical Futurist, “With time, AI solutions will be incorporated in patient monitors as a built-in “smart alarm system” throughout hospital units.”

Image by Bokskapet

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Jun 6, 2023

Americans Give Nurses High Marks for Ethics

Americans give nurses their highest approval for honesty and ethics, rating them above every other profession in a recent Gallup survey that included doctors, school teachers, judges and clergy.

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Conducted in December, Gallup found more Americans than ever say nurses have high or very high standards of honesty and ethics.

While nurses have been at the top of the ratings for 20 of the last 21 years, the COVID pandemic has so spotlighted the work they do that the percentage of survey respondents rating them highly increased by 4 points over 2019. According to Gallup, 89% of Americans gave nurses the highest ratings. Only firefighters have ever scored higher and that was in 2001 shortly after the 9/11 attack when they measured at 90%.

Doctors, who last year were said to have high or very high ethical standards by 65% of survey takers, improved by 12 points. Their previous high of 70% came in 2011 and 2012. Pharmacists, too, improved their standing for honesty and ethics in the view of the public, increasing to 71% from last year’s 64%.

Coming in just behind doctors were grade school teachers (the only teacher category Gallup measured). Their current 75% rating is nine points higher than the last time the group was included which was in 2017 when they were measured at 66%. Gallup says, “This may reflect public appreciation for the risks taken by teachers in going back to school during the pandemic, as well as their commitment to teaching under unprecedented circumstances, whether in the classroom or online.”

Rounding out the top five rankings are police officers who were measured at 52%, a drop of 2 points from the 2019 survey. Despite the decline, they were still one of only five professions to have a majority of Americans rating them high or very high for honesty and ethics.

Gallup’s annual Honesty and Ethics poll surveys a number of different professions each year, with a handful such as nurses, doctors and police officers included consistently. Besides reporting the cumulative results, Gallup breaks down the results by demographics and party affiliation. The divide among the various groups can be substantial for some ratings of professionals.

However, for nurses it didn’t matter whether the respondent was a Democrat, Republican, or Independent, the results were the same. They all thought highly of the profession’s ethics.

Photo by Bermix Studio

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Jun 6, 2023

Wide Scale Testing Beginning for COVID-19 Vaccines

Researchers are making so much progress in developing a vaccine against COVID-19 that the first wide-scale testing could begin in a matter of weeks.

The New York Times Coronavirus Vaccine Tracker says a vaccine developed by the 10-year-old biotech company Moderna expects to start wide-scale testing this month. If it does, it would mark an almost unprecedented acceleration of the clinical testing process.

Typically, testing and approving a new vaccine takes two or three years. Sometimes more. But under the federal government’s Operation Warp Speed, Modena received a fast-track designation from the Food and Drug Administration. It also got a $483 million award to further its Covid-19 vaccine.

Through its Coronavirus Vaccine Tracker The Times is updating the status of all the vaccines that have reached human testing, along with a selection of promising vaccines still being tested in cells or animals. Because of the number and especially speed at which bioscience and pharmaceutical firms are moving to develop a successful vaccine, the Tracker is being updated almost every day.

The World Health Organization lists 149 different vaccine projects underway worldwide. 17 are in clinical evaluation, meaning they are being tested in humans, either in small groups to ensure their safety and basic efficacy, or in hundreds to see the effect among different age groups.

The Vaccine Tracker lists five vaccine candidates that are in or about to launch Phase III testing, the broadest testing category where thousands of volunteers are enlisted to determine if the vaccine is widely effective and how well it protects people from becoming infected. That’s the test Moderna expects to begin soon.

A vaccine developed by AstraZeneca and the University of Oxford is already in Phase III testing in Brazil and South Africa and is in a simultaneous Phase II and III study in Europe. This program, like Moderna’s, is part of Operation Warp Speed.

The Vaccine Tracker lists two Chinese firms – Sinovac Biotech and Sinopharm – as ready to soon start broad testing of their respective vaccines. Sinopharm’s testing will be conducted in the United Arab Emirates. Sinovac plans to conduct its Phase III study in China and Brazil.

A fifth vaccine, which is not a vaccine specifically for COVID-19, but a sort of immune system booster, is being tested in Australia. Bacillus Calmette-Guerin, a vaccine originally developed for tuberculosis, has been found over its 100 year history to help fight off other types of infections and parasites. The Phase III testing will determine if it also helps protect against COVID-19.

Image by Angelo Esslinger

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