Exciting Research Associate opportunity to support process development of gene therapy products.
Job Detail
Job Description
Summary:
The Research Associate will perform analytical chemistry and biophysical methods for the testing of AAV gene therapy products, to support process development and product characterizations.
Responsibilities:
- Perform UV, HPLC, SV-AUC and CE-based methods to quantitatively measure the purity of the AAV gene therapy vectors and support process development.
- Assess and implement new analytical platforms, such as DLS, SEC-MALS, etc., to determine AAV capsid identity, quality, and quantity.
- Investigate and evaluate cutting edge biophysical and analytical instrumentation.
- Write, prepare and present technical data, technical reports and standard operating procedures (SOPs) for internal use and transfer to external sites.
- Provide technical support to cross-function groups and external collaborators.
Qualifications:
- BS or MS in Biophysics, Biochemistry, Analytical Chemistry or a related discipline with relevant lab experience. 1-2 years of industry experience is preferred.
- HPLC/UPLC experience analyzing nucleic acids, virus capsids, antibodies and/or other biologics materials by a variety of chromatographic methods (RP, SEC, IEX, SEC/FFF-MALS)
- Experience with SV-AUC analyzing Viral vectors or proteins is preferred.
- Experience with CE-SDS and cIEF, for the analysis of biological materials is desired.
- Working experience in viral particle analysis is highly desired.
- Excellent laboratory, computer, documentation, and organization skills
- Strong collaborative work ethic and excellent time management skills for ongoing testing in parallel with new method development, in a fast-paced, scientifically rigorous, cross-functional team environment
Required skills
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