06Jun

The shortage of masks, respirators and other medical supplies that accompanied the rise of COVID-19 cases has added momentum to government efforts to encourage the onshoring of medical manufacturing.

Since the beginning of the year, the US government through the Biomedical Advanced Research and Development Authority (BARDA) has awarded at least billion dollars to bioscience and contract development and manufacturing organizations to create or expand production capability in the US.

In May, four-month old drug manufacturer Phlow got a $354 million award from the federal government to manufacture generic medicines and pharmaceutical ingredients that are needed to treat Covid-19.

In June, Emergent BioSolutions announced a $628 million deal with the government to commit its Baltimore facility manufacturing capacity for production of COVID-19 vaccine candidates through 2021.

Last week, Grand River Aseptic Manufacturing, announced it had completed work on a $60 million privately financed expansion of its Michigan fill/finish facility. GRAM is a contract development and manufacturing firm that completes the final, sterile packaging of injectable drugs for companies that developed or market them.

These are just the latest examples of what FiercePharma describes as a “growing wave of manufacturers and drugmakers pitching their domestic footprint.”

While political interest in bringing drug manufacturing back to the US isn’t new, the current pandemic has given the effort greater momentum. A raft of legislation has been introduced in Congress from both sides of the aisle. FiercePharma says a bill by Arkansas Republican Sen. Tom Cotton “would require government payers to phase out reimbursement for drugs made or sourced in China by 2022. Other bills have also directly targeted China’s role in the supply chain as a possible national security issue.”

The White House said it is working on an executive order to require federal agencies to purchase only US made medical products and drugs.

Though the pharmaceutical industry is opposed to compelling all manufacturing to move to the US, the political winds, not to mention the incentives the government is dangling, is beginning to interest investors.

The real estate equities firm Lincoln Equities Group and H.I.G. Realty Partners, the real estate arm of private equity firm H.I.G. Capital, LLC, which owns the 422 acre former Bristol Myers Squibb lifesciences campus in New Jersey, is making a direct pitch to pharmaceutical manufacturing firms to locate there.

“Given the current public health crisis, we anticipate pharmaceutical and life sciences manufacturers to consider ‘reshoring’ and expanding operations in the U.S.,” said Joel Bergstein, president of Lincoln Equities. “This spacious, modern BMS campus – located in the center of ‘Einstein’s Alley’ in Central New Jersey – is a prime location for continued innovation and expansion.”

Image courtesy Grand River Aseptic Manufacturing

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Jun 6, 2023

Wearables That Print On Your Body

Biomedical sensors long ago moved out of the hospital and into an assortment of recreational exercise devices monitoring heart rate, blood pressure, respiration and other vital signs.

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Whether medical or recreational activity trackers, these sensors require some sort of carrier — think wristbands or EKG electrode patches — which limits their effectiveness and can make them uncomfortable when worn for extended periods. They can also be hard to place and often have poor signal quality.

Now, right out of science fiction, engineers at Penn State, China’s Harbin Institute of Technology and other Chinese institutions have come up with a way to print the sensors and their electronics directly on human skin.

Up to now, the only way to bond nanoparticles together to create flexible electronics was through a process requiring temperatures hotter than the hottest home oven. The new process uses common materials that allow the particles to bond at room temperature.

The resulting sensor is flexible, smooth and durable enough to remain on the skin until peeled off with hot water. The devices can then be recycled and reused.

Lead researcher, Penn State Engineering Professor Huanyu Cheng, explained that the bonding process uses polyvinyl alcohol paste — the main ingredient in peelable face masks — and calcium carbonate — the key ingredient of eggshells.

The sensors, he said, “Are capable of precisely and continuously capturing temperature, humidity, blood oxygen levels and heart performance signals.”

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Jun 6, 2023

You Don’t Have to Be a Scientist to Have a Life Sciences Career

Curious about a career in the life sciences industry, but you’re not a scientist? Don’t let that discourage you. Pharmaceutical companies have thousands of jobs in a variety of areas that don’t require biology or other science background.

The challenge for new entrants is that recruiters look for great talent with relevant experience. Whether you’re a recent or upcoming grad or a mid-career professional wanting to change industries, it’s up to you to show how your background and the experience you have is relevant. That means showing how your skills are transferable.

For example, an accountant who helped develop sales projections for a new product or territory may be able to demonstrate how the research and analysis that went into the report applies in the pharmaceutical world. A marketer with lead generation experience should explain how that can help the company expand sales.

Biospace has a primer on using skills and experience in other jobs to open career opportunities in the life sciences sector. The advice is basic, yet what it lacks in specifics it makes up for in providing direction.

For starters, Biospace counsels to “Get clear on what your transferable skills are.” As commonsense as that is, so many job seekers will start by simply updating an existing resume.

Don’t!

First become knowledgeable about the skills important to life sciences and pharmaceutical firms. Inventory the skills you’ve developed and your experience, listing those most relevant and transferable.

“Some suggestions to consider,” says the article, ”Are research, analysis, data analysis, problem solving, communication, time management, communication (written and verbal), planning, strategizing, team management, project management, presenting, conflict resolution, collaboration and training.”

Then “Come up with examples from your past job roles and duties.” Finally, “Include accomplishments that emphasize the transferable skills.”

Now you’re ready to revise your resume to highlight those skills and show how they will benefit the company.

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