06Jun

In a year of “unparalleled economic and healthcare shocks,” Informa’s Global Pharma Insights says the pharmaceutical industry is still healthy even as “COVID-19’s implications for pharma growth, revenues and the supply chain are still emerging.”

CPhI’s Pharma Industry Rankings & Annual Industry Report 2020 shows how pharmaceutical executives from across the globe assess the state of the industry, ranking the major pharma markets on a range of indicators including growth potential and innovation.

The overall industry index, which is a compilation of the scores across each market, fell for the first time in four years. The index reflects the accumulated scores in five main areas: growth, API manufacturing, finished dose manufacturing, competitiveness, and knowledge of professionals.

While the report doesn’t specifically explain the decline in the overall index, it’s apparent that China’s sharp decline in several categories was a key factor.

“It is China,” the report says, “That has suffered the biggest score decrease of 5.80%, which sees them fall down the rankings into 10th place.” China’s role and its lack of transparency in the early months of the pandemic “has negatively impacted the Chinese pharma market’s reputation in nearly all major sub-sectors,” notes the report, reflecting the views of the survey’s 550 respondents.

However, the report predicts that the effects will be short term. “China’s fundamentals remain too strong. We expect a dramatic bounce for China in 2021.”

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Despite the decline of 7 of the 10 countries detailed in the rankings, the report says “many of the leading pharma economies have scored strongly in knowledge and pharmaceutical quality statistics and much of the fall on 2019 results reflects reduced confidence in growth rather than quality.”

The United States fared well, coming out on top in the CPhI Pharma Index with a score of 7.41. Japan and Germany followed in 2nd and 3rd place. In terms of market growth potential, India was the big winner, coming out on top in rankings for the category for the first time. The country, like China, has long benefited from the outsourcing of high-volume production. This year, as Big Pharma and smaller firms sought to de-risk their global supply chain, India became the primary beneficiary of this rebalancing.

Photo by Isaac Quesada on Unsplash

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Jun 6, 2023

What’s the Difference Between the COVID Vaccines?

With the approval last month of the Moderna vaccine by the Food and Drug Administration, we now have two COVID-19 vaccines available. Two more – one from Johnson & Johnson the other from AstraZeneca – are on the way and could be approved as soon as February.

Healthcare workers, residents of nursing facilities and some first responders have already received the Pfizer vaccine, the first one approved by the FDA. Moderna has begun shipping its vaccine with the first of the 25 million initial doses administered last month.

People eager to be immunized have inundated doctors’ offices and clinics asking when the vaccine will be available. The best answer is soon.

Which one, though, will you receive? And does it make any difference?

The answer to the first question is whichever vaccine can be obtained the quickest or, in some cases, whichever your health plan recommends. It really doesn’t make any difference to you.

Both vaccines require two separate doses to reach maximum effectiveness 21 days apart for Pfizer and 28 days for the Moderna version. Both protect about equally well. The FDA data shows Pfizer is 95% effective after both doses. Moderna is 94.1%.

Unlike most other vaccines, these two vaccines use pieces of protein from the SARS-CoV-2 virus to prompt the body to create antibodies. Conventional vaccines, like the annual flu shot, are manufactured from viruses typically grown in chicken eggs. These chicken grown viruses are then killed or weakened to become vaccines.

The COVID vaccines employ messenger RNA (mRNA), a newer technology. These vaccines “teach” the body to replicate the little bit of the CoV-2 protein, which, in turn, creates an immune response causing the body to make the antibodies that provide the protection against the virus.

The most significant difference between the Moderna and the Pfizer vaccines is how they must be stored. Both can survive for a few days in standard refrigeration. For longer periods, the less stable Pfizer vaccine must be kept in ultra-low temperatures below -94 F. That makes shipping and storing Pfizer’s vaccine somewhat more complicated, especially outside urban areas where the low temperature refrigeration is not easily available.

“At the end of the day, these two vaccines are pretty similar,” Dr. Thomas Russo, professor and chief of infectious disease at the State University of New York, tells Health. “Grab it while you can.”

Photo by Hakan Nural

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